| ID | SAVERM_2025
| Type | CDS
|
| From | 2465738
| nt length | 918
|
| To | 2466655
| aa length | 305
|
| Gene | garR
| pI | 5.15
|
| Definition | putative 2-hydroxy-3-oxopropionate reductase
| M.W (Da) | 31138
|
| Note | PF03446: NAD binding domain of 6-phosphogluconate dehydrogenase
| AseI frg. | C
|
| SignalP v.4.0 | Non-secretory protein | plot
| Category | specific pathways
|
Orthologs (if any)
| Bacteria* | Reciprocally best hit to | Score | E-value
|
| coel | SCO6205 putative dehydrogenase | 517 | 0.0e+00
|
| sgr | SGR_1322 putative dehydrogenase | 521 | 0.0e+00
|
| sam | SAM23877_5945 2-hydroxy-3-oxopropionate reductase | 516 | 0.0e+00
|
| scab | SCAB18581 putative 2-hydroxy-3-oxopropionate reductase | 481 | 2.0e-174
|
| sace | SACE_1936 2-hydroxy-3-oxopropionate reductase | 329 | 3.0e-114
|
| nfar | nfa10400 3-hydroxyisobutyrate dehydrogenase | 163 | 2.0e-41
|
| mtub | gi|15607891 PROBABLE 3-HYDROXYISOBUTYRATE DEHYDROGENASE MMSB (HIBADH) [Mycobacterium tuberculosis H37Rv] | 171 | 7.3e-44
|
| bsub | BG13328 ykwC; similar to 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31] | 189 | 1.3e-49
|
| ecoli | gi|16131017 tartronate semialdehyde reductase (TSAR) [Escherichia coli K12] | 252 | 2.5e-68
|
| paer | PA1500 [gene=PA1500] [prot=probable oxidoreductase] [comment=PA1500] | 219 | 3.2e-58
|
*coel, Streptomyces coelicolor A3(2); sgr, Streptomyces griseus IFO13350; sam, Streptomyces ambofaciens ATCC 23877; scab, Streptomyces scabies 87.22; sace, Saccharopolyspora erythraea NRRL2338; nfar, Nocardia farcinica IFM 10152; mtub, Mycobacterium tuberculosis H37Rv; bsub, Bacillus subtilis; ecoli, Escherichia coli K-12; paer, Pseudomonas aeruginosa;
Pfam search result
| Model | No. | Description | Position (aa) | Score | E-value
|
| NAD_binding_2 | 1 | NAD binding domain of 6-phosphogluconate dehydrogenase | 16-174 | 169.4 | 6.2e-50
|
| NAD_binding_11 | 1 | NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase | 177-295 | 138.0 | 1.7e-40
|
| F420_oxidored | 1 | NADP oxidoreductase coenzyme F420-dependent | 16-106 | 31.3 | 2.2e-07
|
| IlvN | 1 | Acetohydroxy acid isomeroreductase, NADPH-binding domain | 16-84 | 23.1 | 4.1e-05
|
BLAST search result (top 10 hits)
| ID | Description | Score | E-value
|
| WP_190171460.1 | 2-hydroxy-3-oxopropionate reductase [Streptomyces mirabilis]...
| 1160 | 4.4e-158 |
| WP_168530797.1 | 2-hydroxy-3-oxopropionate reductase [Streptomyces sp. RPA4-2...
| 1157 | 6.4e-158 |
| WP_168497088.1 | MULTISPECIES: 2-hydroxy-3-oxopropionate reductase [Streptomy...
| 1158 | 8.8e-158 |
| WP_107016691.1 | 2-hydroxy-3-oxopropionate reductase [Streptomyces dioscori] ...
| 1156 | 1.3e-157 |
| WP_099919977.1 | 2-hydroxy-3-oxopropionate reductase [Streptomyces sp. GbtcB7...
| 1156 | 1.8e-157 |
| WP_075032869.1 | 2-hydroxy-3-oxopropionate reductase [Streptomyces mirabilis]...
| 1154 | 3.5e-157 |
| WP_095851874.1 | 2-hydroxy-3-oxopropionate reductase [Streptomyces sp. Ag82_O...
| 1154 | 4.1e-157 |
| WP_033324640.1 | 2-hydroxy-3-oxopropionate reductase [Streptomyces yerevanens...
| 1152 | 4.2e-157 |
| WP_210888604.1 | 2-hydroxy-3-oxopropionate reductase [Streptomyces sp. BH-SS-...
| 1152 | 5.4e-157 |
| WP_155060288.1 | 2-hydroxy-3-oxopropionate reductase [Streptomyces blattellae...
| 1152 | 5.8e-157 |
PSORT result
| Localization | Certainty | PSORT said
|
| membrane | 0.2805 | Seems to have no N-terminal signal seq.
|