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IDSAVERM_419 TypeCDS
From567017 nt length23241
To543777 aa length7746
GenepteA1 pI4.71
Definitionmodular polyketide synthase M.W (Da)806343
Notefilipin gene cluster AseI frg.A
SignalP v.4.0Non-secretory protein | plot Categoryantibiotic production


Orthologs (if any)

Bacteria*Reciprocally best hit toScoreE-value
sgrSGR_6372 putative type-I PKS41430.0e+00
samSAM23877_5625 modular polyketide synthase (KS0-AT-ACP-KS-AT-KR-ACP-KS-AT-DH-KR-ACP)33360.0e+00
saceSACE_4140 type I modular polyketide synthase31550.0e+00
paerPA2968 [gene=fabD] [prot=malonyl-CoA-[acyl-carrier-protein] transacylase] [comment=PA2968]1444.1e-34

*sgr, Streptomyces griseus IFO13350; sam, Streptomyces ambofaciens ATCC 23877; sace, Saccharopolyspora erythraea NRRL2338; paer, Pseudomonas aeruginosa;

Pfam search result



ModelNo.DescriptionPosition (aa)ScoreE-value

ketoacyl-synt5Beta-ketoacyl synthase, N-terminal domain23-269, 1046-1296, 2552-2802, 4286-4536, 5972-62221507.80

Acyl_transf_15Acyl transferase domain552-874, 1578-1879, 3081-3382, 4815-5116, 6501-6799904.42.5e-273

KR4KR domain2177-2352, 3909-4087, 5608-5778, 7309-7484729.67.6e-222

Ketoacyl-synt_C5Beta-ketoacyl synthase, C-terminal domain277-394, 1304-1421, 2810-2927, 4544-4661, 6230-6347717.23.6e-220

PS-DH3Polyketide synthase dehydratase3428-3716, 5162-5433, 6849-7124546.99.9e-165

KAsynt_C_assoc5Ketoacyl-synthetase C-terminal extension397-516, 1424-1509, 2930-3045, 4664-4751, 6350-6465268.06.8e-81

PP-binding5Phosphopantetheine attachment site958-1023, 2461-2527, 4194-4260, 5883-5949, 7592-7657230.71.1e-69

adh_short4short chain dehydrogenase2178-2335, 3910-4070, 5608-5761, 7309-7471154.91.6e-45

Thiolase_N4Thiolase, N-terminal domain1197-1253, 2712-2757, 4432-4489, 6128-6182124.25.2e-36

Epimerase1NAD dependent epimerase/dehydratase family2179-231472.14.2e-20

Polysacc_synt_21Polysaccharide biosynthesis protein2179-226248.18.1e-13

BLAST search result (top 10 hits)

ID DescriptionScoreE-value
WP_069933651.1 type I polyketide synthase [Streptomyces agglomeratus] >gb 308600.0e+00
WP_058042044.1 type I polyketide synthase [Streptomyces roseifaciens] 298750.0e+00
WP_190021271.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces hir... 297810.0e+00
PSJ28271.1 polyketide synthase [Streptosporangium nondiastaticum] 297680.0e+00
WP_120752862.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces kle... 296580.0e+00
296230.0e+00
WP_228774853.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces sp.... 296050.0e+00
WP_179084379.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces rec... 295800.0e+00
WP_162131798.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces sp.... 292660.0e+00
WP_199572375.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces mur... 292070.0e+00

PSORT result

LocalizationCertaintyPSORT said
membrane0.2211 Seems to have no N-terminal signal seq.