| ID | SAVERM_4741
| Type | CDS
|
| From | 5780485
| nt length | 1716
|
| To | 5782200
| aa length | 571
|
| Gene | hemD
| pI | 5.78
|
| Definition | putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase
| M.W (Da) | 59683
|
| Note | PF02602: Uroporphyrinogen-III synthase HemD
| AseI frg. | I
|
| SignalP v.4.0 | Non-secretory protein | plot
| Category | metabolism of coenzymes & prosthetic groups
|
Orthologs (if any)
| Bacteria* | Reciprocally best hit to | Score | E-value
|
| coel | SCO3317 putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase | 1004 | 0.0e+00
|
| sgr | SGR_4157 putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase | 936 | 0.0e+00
|
| sam | SAM23877_4242 Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase | 989 | 0.0e+00
|
| scab | SCAB39061 putative uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase | 986 | 0.0e+00
|
| sace | SACE_6944 uroporphyrinogen III synthase/methyltransferase | 479 | 1.0e-165
|
| nfar | nfa51680 hemDX uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase | 498 | 7.3e-142
|
| mtub | gi|57116747 PROBABLE UROPORPHYRIN-III C-METHYLTRANSFERASE HEMD (UROPORPHYRINOGEN III METHYLASE) (UROGEN III METHYLASE) (SUMT) (UROGEN III METHYLASE) (UROM) [Mycobacterium tuberculosis H37Rv] | 485 | 2.9e-138
|
| cglu | gi|19551674 COG0007:Uroporphyrinogen-III methylase [Corynebacterium glutamicum] | 434 | 6.9e-123
|
*coel, Streptomyces coelicolor A3(2); sgr, Streptomyces griseus IFO13350; sam, Streptomyces ambofaciens ATCC 23877; scab, Streptomyces scabies 87.22; sace, Saccharopolyspora erythraea NRRL2338; nfar, Nocardia farcinica IFM 10152; mtub, Mycobacterium tuberculosis H37Rv; cglu, Corynebacterium glutamicum;
Pfam search result
| Model | No. | Description | Position (aa) | Score | E-value
|
| HEM4 | 1 | Uroporphyrinogen-III synthase HemD | 304-531 | 217.3 | 1.6e-64
|
| TP_methylase | 1 | Tetrapyrrole (Corrin/Porphyrin) Methylases | 14-245 | 116.8 | 1.2e-33
|
BLAST search result (top 10 hits)
| ID | Description | Score | E-value
|
| WP_164369513.1 | bifunctional uroporphyrinogen-III C-methyltransferase/uropor...
| 2377 | 0.0e+00 |
| WP_081218675.1 | bifunctional uroporphyrinogen-III C-methyltransferase/uropor...
| 2375 | 0.0e+00 |
| WP_189190648.1 | bifunctional uroporphyrinogen-III C-methyltransferase/uropor...
| 2375 | 0.0e+00 |
| WP_099506177.1 | MULTISPECIES: bifunctional uroporphyrinogen-III C-methyltran...
| 2371 | 0.0e+00 |
| WP_095935825.1 | uroporphyrinogen-III synthase [Streptomyces sp. Tue6028]
| 2370 | 0.0e+00 |
| WP_037627359.1 | bifunctional uroporphyrinogen-III C-methyltransferase/uropor...
| 2366 | 0.0e+00 |
| WP_189860713.1 | bifunctional uroporphyrinogen-III C-methyltransferase/uropor...
| 2353 | 0.0e+00 |
| WP_189287348.1 | bifunctional uroporphyrinogen-III C-methyltransferase/uropor...
| 2348 | 0.0e+00 |
| WP_028805579.1 | uroporphyrinogen-III synthase [Streptomyces sp. 142MFCol3.1]
| 2347 | 0.0e+00 |
| WP_037684125.1 | bifunctional uroporphyrinogen-III C-methyltransferase/uropor...
| 2342 | 0.0e+00 |
PSORT result
| Localization | Certainty | PSORT said
|
| membrane | 0.1404 | Seems to have no N-terminal signal seq.
|