| ID | SAVERM_5452
| Type | CDS
|
| From | 6614987
| nt length | 1362
|
| To | 6616348
| aa length | 453
|
| Gene | folC
| pI | 4.26
|
| Definition | putative folylpolyglutamate synthase
| M.W (Da) | 48037
|
| Note | PF01225: Mur ligase family, catalytic domain
| AseI frg. | B
|
| SignalP v.4.0 | Non-secretory protein | plot
| Category | metabolism of coenzymes & prosthetic groups
|
Orthologs (if any)
| Bacteria* | Reciprocally best hit to | Score | E-value
|
| coel | SCO2614 fpgS folylpolyglutamate synthase | 756 | 0.0e+00
|
| sgr | SGR_4928 putative folylpolyglutamate synthase | 751 | 0.0e+00
|
| sam | SAM23877_2661 Folylpolyglutamate synthase | 757 | 0.0e+00
|
| scab | SCAB59991 putative folylpolyglutamate synthase | 789 | 0.0e+00
|
| sace | SACE_1387 folylpolyglutamate synthase | 513 | 0.0e+00
|
| nfar | nfa13490 folC folylpolyglutamate synthetase | 520 | 1.1e-148
|
| mtub | gi|15609584 PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) [Mycobacterium tuberculosis H37Rv] | 476 | 1.3e-135
|
| cglu | gi|19553574 COG0285:Folylpolyglutamate synthase [Corynebacterium glutamicum] | 490 | 4.8e-140
|
| bsub | BG10322 folC; folylpolyglutamate synthase [EC:6.3.2.17] | 187 | 1.1e-48
|
| ecoli | gi|16130250 dihydrofolate:folylpolyglutamate synthetase; dihydrofolate synthetase [Escherichia coli K12] | 153 | 2.6e-38
|
| paer | PA3111 [gene=folC] [prot=folylpolyglutamate synthetase] [comment=PA3111] | 142 | 6.2e-35
|
*coel, Streptomyces coelicolor A3(2); sgr, Streptomyces griseus IFO13350; sam, Streptomyces ambofaciens ATCC 23877; scab, Streptomyces scabies 87.22; sace, Saccharopolyspora erythraea NRRL2338; nfar, Nocardia farcinica IFM 10152; mtub, Mycobacterium tuberculosis H37Rv; cglu, Corynebacterium glutamicum; bsub, Bacillus subtilis; ecoli, Escherichia coli K-12; paer, Pseudomonas aeruginosa;
Pfam search result
| Model | No. | Description | Position (aa) | Score | E-value
|
| Mur_ligase_M | 1 | Mur ligase middle domain | 56-283 | 54.4 | 1.4e-14
|
| Mur_ligase_C | 1 | Mur ligase family, glutamate ligase domain | 312-390 | 48.3 | 8.1e-13
|
BLAST search result (top 10 hits)
| ID | Description | Score | E-value
|
| OPG03377.1 | dihydrofolate synthase [Streptomyces sp. GKU 895]
| 1859 | 0.0e+00 |
| WP_059191775.1 | bifunctional folylpolyglutamate synthase/dihydrofolate synth...
| 1859 | 0.0e+00 |
| NUO40453.1 | bifunctional folylpolyglutamate synthase/dihydrofolate synthase [...
| 1852 | 0.0e+00 |
| NUR44132.1 | bifunctional folylpolyglutamate synthase/dihydrofolate synthase [...
| 1852 | 0.0e+00 |
| WP_097264074.1 | bifunctional folylpolyglutamate synthase/dihydrofolate synth...
| 1851 | 0.0e+00 |
|
| 1850 | 0.0e+00 |
| WP_126271891.1 | bifunctional folylpolyglutamate synthase/dihydrofolate synth...
| 1850 | 0.0e+00 |
| WP_030934328.1 | bifunctional folylpolyglutamate synthase/dihydrofolate synth...
| 1849 | 0.0e+00 |
| WP_123965114.1 | bifunctional folylpolyglutamate synthase/dihydrofolate synth...
| 1846 | 0.0e+00 |
| WP_109498822.1 | bifunctional folylpolyglutamate synthase/dihydrofolate synth...
| 1845 | 0.0e+00 |
PSORT result
| Localization | Certainty | PSORT said
|
| membrane | 0.1086 | Seems to have no N-terminal signal seq.
|