-- | --

IDSAVERM_938 TypeCDS
From1137817 nt length11919
To1149735 aa length3972
GeneaveA1 pI6.37
Definitiontype I polyketide synthase AVES 1 M.W (Da)416860
Noteavermectin gene cluster AseI frg.A
SignalP v.4.0Non-secretory protein | plot Categoryantibiotic production


Orthologs (if any)

Bacteria*Reciprocally best hit toScoreE-value

Pfam search result



ModelNo.DescriptionPosition (aa)ScoreE-value

Acyl_transf_13Acyl transferase domain29-350, 1050-1368, 2638-2938743.32.7e-224

ketoacyl-synt2Beta-ketoacyl synthase, N-terminal domain481-735, 2086-2336597.22.6e-180

KR2KR domain1715-1893, 3537-3716368.84.1e-111

Ketoacyl-synt_C2Beta-ketoacyl synthase, C-terminal domain743-859, 2344-2461290.76e-88

PS-DH1Polyketide synthase dehydratase3005-3300157.05.5e-46

PP-binding3Phosphopantetheine attachment site400-451, 1994-2059, 3821-3886137.01.9e-40

KAsynt_C_assoc2Ketoacyl-synthetase C-terminal extension862-1012, 2464-2592121.91.6e-35

adh_short1short chain dehydrogenase3539-369659.42.9e-16

Thiolase_N1Thiolase, N-terminal domain2230-229054.11.3e-14

BLAST search result (top 10 hits)

ID DescriptionScoreE-value
WP_237529128.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces sp.... 81170.0e+00
WP_052808535.1 type I polyketide synthase [Streptomyces cyaneogriseus] 38380.0e+00
BAF85838.1 modular polyketide synthase [Streptomyces cyaneogriseus subsp. n... 38050.0e+00
BAF85839.1 modular polyketide synthase [Streptomyces cyaneogriseus subsp. n... 32510.0e+00
WP_052808536.1 type I polyketide synthase [Streptomyces cyaneogriseus] 32420.0e+00
WP_157165045.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces typ... 31750.0e+00
ADI03847.1 type I polyketide synthase [Streptomyces bingchenggensis BCW-1] 31430.0e+00
WP_053161307.1 type I polyketide synthase [Streptomyces caatingaensis] 31420.0e+00
ARQ84055.1 milbemycin biosynthetic protein MilA3 [Streptomyces hygroscopicus... 30980.0e+00
ADC45538.1 modular polyketide synthase [Streptomyces nanchangensis] 30920.0e+00

PSORT result

LocalizationCertaintyPSORT said
membrane0.2317 Seems to have no N-terminal signal seq.