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IDSAVERM_939 TypeCDS
From1149787 nt length18720
To1168506 aa length6239
GeneaveA2 pI6.41
Definitiontype I polyketide synthase AVES 2 M.W (Da)666306
Noteavermectin gene cluster AseI frg.A
SignalP v.4.0Non-secretory protein | plot Categoryantibiotic production


Orthologs (if any)

Bacteria*Reciprocally best hit toScoreE-value

Pfam search result



ModelNo.DescriptionPosition (aa)ScoreE-value

ketoacyl-synt4Beta-ketoacyl synthase, N-terminal domain36-287, 1083-1333, 2680-2930, 4271-45231208.70

Acyl_transf_14Acyl transferase domain597-908, 1654-1943, 3231-3517, 4815-5133732.16.7e-221

Ketoacyl-synt_C4Beta-ketoacyl synthase, C-terminal domain295-412, 1341-1458, 2938-3055, 4531-4648565.53.9e-173

KR3KR domain2306-2484, 3878-4057, 5753-5932546.21.5e-165

KAsynt_C_assoc4Ketoacyl-synthetase C-terminal extension415-551, 1461-1608, 3058-3185, 4651-4777247.91.2e-74

PS-DH1Polyketide synthase dehydratase5189-5494182.31.1e-53

PP-binding4Phosphopantetheine attachment site993-1059, 2596-2656, 4175-4240, 6047-6113172.71.3e-51

Thiolase_N4Thiolase, N-terminal domain197-240, 1229-1287, 2822-2885, 4409-4479112.32.2e-32

adh_short2short chain dehydrogenase3880-4038, 5754-591490.58.7e-26

Docking1Erythronolide synthase docking4-2939.04e-10

BLAST search result (top 10 hits)

ID DescriptionScoreE-value
WP_052808536.1 type I polyketide synthase [Streptomyces cyaneogriseus] 52850.0e+00
ADC45534.1 modular polyketide synthase [Streptomyces nanchangensis] 45730.0e+00
BAF85839.1 modular polyketide synthase [Streptomyces cyaneogriseus subsp. n... 44960.0e+00
WP_237529128.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces sp.... 41450.0e+00
ADC45538.1 modular polyketide synthase [Streptomyces nanchangensis] 39030.0e+00
WP_013005780.1 type I polyketide synthase [Streptomyces scabiei] >emb 37350.0e+00
WP_210533013.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces sp.... 37340.0e+00
WP_210524220.1 MULTISPECIES: SDR family NAD(P)-dependent oxidoreductase [un... 37300.0e+00
WP_210551614.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces sp.... 37280.0e+00
WP_144001412.1 SDR family NAD(P)-dependent oxidoreductase [Streptomyces spe... 37280.0e+00

PSORT result

LocalizationCertaintyPSORT said
membrane0.2381 Seems to have no N-terminal signal seq.